Epilepsy

Failure of the Nemo Trial: Bumetanide Is a Promising Agent to Treat Many Brain Disorders but Not Newborn Seizures

Ben-Ari Y, Damier P, Lemmonnier E.
Front Cell Neurosci. 2016 Apr 14;10:90.
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Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model.

Lozovaya N, Gataullina S, Tsintsadze T, Tsintsadze V, Pallesi-Pocachard E, Minlebaev M, Goriounova NA, Buhler E, Watrin F, Shityakov S, Becker AJ, Bordey A, Milh M, Scavarda D, Bulteau C, Dorfmuller G, Delalande O, Represa A, Cardoso C, Dulac O, Ben-Ari Y, Burnashev N.
Nat Commun. 2014 Aug 1 ; 5:4563.
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Mechanisms and effects of seizures in the immature brain. Semin Fetal Neonatal Med.

Nardou R, Ferrari DC, Ben-Ari Y.
Semin Fetal Neonatal Med. 2013 Aug ; 18(4):175-84.
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Tubacin prevents neuronal migration defects and epileptic activity caused by rat Srpx2 silencing in utero.

Salmi M, Bruneau N, Cillario J, Lozovaya N, Massacrier A, Buhler E, Cloarec R, Tsintsadze T, Watrin F, Tsintsadze V, Zimmer C, Villard C, Lafitte D, Cardoso C, Bao L, Lesca G, Rudolf G, Muscatelli F, Pauly V, Khalilov I, Durbec P, Ben-Ari Y, Burnashev N, Represa A, Szepetowski P.
Brain. 2013 Aug ; 136(Pt 8):2457-73.
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Blocking seizures with the diuretic bumetanide: promises and pitfalls.

Ben-Ari Y.
Epilepsia. 2012 Feb ; 53(2):394-6.
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Kainate and Temporal Lobe Epilepsies: 3 decades of progress.

Ben-Ari Y.
In: Jasper’s Basic Mechanisms of the Epilepsies [Internet]. 4th edition. Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, editors. Bethesda (MD): National Center for Biotechnology Information (US); 2012.
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Is it safe to use a diuretic to treat seizures early in development?

Ben-Ari Y, Tyzio R.
Epilepsy Curr. 2011 Nov ; 11(6):192-5.
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Enhanced Synaptic Activity and Epileptiform Events in the Embryonic KCC2 Deficient Hippocampus.

Khalilov I, Chazal G, Chudotvorova I, Pellegrino C, Corby S, Ferrand N, Gubkina O, Nardou R, Tyzio R, Yamamoto S, Jentsch TJ, Hübner CA, Gaiarsa JL, Ben-Ari Y, Medina I.
Front Cell Neurosci. 2011 Nov 1 ; 5:23.
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Neuronal chloride accumulation and excitatory GABA underlie aggravation of neonatal epileptiform activities by phenobarbital.

Nardou R, Yamamoto S, Chazal G, Bhar A, Ferrand N, Dulac O, Ben-Ari Y, Khalilov I.
Brain. 2011 Apr ; 134(Pt 4):987-1002.
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Primary and secondary mechanisms of epileptogenesis in the temporal lobe: there is a before and an after.

Ben-Ari Y, Dudek FE.
Epilepsy Curr. 2010 Sep ; 10(5):118-25.
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Layer-specific generation and propagation of seizures in slices of developing neocortex: role of excitatory GABAergic synapses.

Rheims S, Represa A, Ben-Ari Y, Zilberter Y.
J Neurophysiol. 2008 Aug ; 100(2):620-8.
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Bumetanide, an NKCC1 antagonist, does not prevent formation of epileptogenic focus but blocks epileptic focus seizures in immature rat hippocampus.

Nardou R, Ben-Ari Y, Khalilov I.
J Neurophysiol. 2009 Jun ; 101(6):2878-88.
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Seizures beget seizures in temporal lobe epilepsies: the boomerang effects of newly formed aberrant kainatergic synapses.

Ben-Ari Y, Crepel V, Represa A.
Epilepsy Curr. 2008 May-Jun ; 8(3):68-72.
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Late-onset epileptogenesis and seizure genesis: lessons from models of cerebral ischemia.

Epsztein J, Ben-Ari Y, Represa A, Crépel V.
Neuroscientist. 2008 Feb ; 14(1):78-90.
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Antiepileptic drugs and brain maturation: fetal exposure to lamotrigine generates cortical malformations in rats.

Manent JB, Jorquera I, Franco V, Ben-Ari Y, Perucca E, Represa A.
Epilepsy Res. 2008 Feb ; 78(2-3):131-9.

Epilepsies and neuronal plasticity: for better or for worse?

Ben-Ari Y.
Dialogues Clin Neurosci. 2008 ; 10(1):17-27.
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A single episode of neonatal seizures permanently alters glutamatergic synapses.

Holmes GL, Ben-Ari Y.
Ann Neurol. 2007 May ; 61(5):379-81.

Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias.

Manent JB, Jorquera I, Mazzucchelli I, Depaulis A, Perucca E, Ben-Ari Y, Represa A.
Epilepsia. 2007 Apr ; 48(4):684-93.
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Quantal release of glutamate generates pure kainate and mixed AMPA/kainate EPSCs in hippocampal neurons.

Cossart R, Epsztein J, Tyzio R, Becq H, Hirsch J, Ben-Ari Y, Crépel V.
Neuron. 2002 Jul 3 ; 35(1):147-59.
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Developing networks play a similar melody.

Ben-Ari Y.
Trends Neurosci. 2001 Jun ; 24(6):353-60.
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Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy.

Cossart R, Dinocourt C, Hirsch JC, Merchan-Perez A, De Felipe J, Ben-Ari Y, Esclapez M, Bernard C.
Nat Neurosci. 2001 Jan ; 4(1):52-62.
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Kainate, a double agent that generates seizures: two decades of progress.

Ben-Ari Y, Cossart R.
Trends Neurosci. 2000 Nov ; 23(11):580-7.
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Seizures in the developing brain: perhaps not so benign after all.

Holmes GL, Ben-Ari Y.
Neuron. 1998 Dec ; 21(6):1231-4.
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Operative GABAergic inhibition in hippocampal CA1 pyramidal neurons in experimental epilepsy.

Esclapez M, Hirsch JC, Khazipov R, Ben-Ari Y, Bernard C.
Proc Natl Acad Sci U S A. 1997 Oct 28 ; 94(22):12151-6.
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Sprouting of mossy fibers in the hippocampus of epileptic human and rat.

Represa A, Tremblay E, Ben-Ari Y.
Adv Exp Med Biol. 1990 ; 268:419-24.
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Kainate binding sites in the hippocampal mossy fibers: localization and plasticity.

Represa A, Tremblay E, Ben-Ari Y.
Neuroscience. 1987 Mar ; 20(3):739-48.
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Limbic seizure and brain damage produced by kainic acid: mechanisms and relevance to human temporal lobe epilepsy.

Ben-Ari Y.
Neuroscience. 1985 Feb ; 14(2):375-403
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Maturation of kainic acid seizure-brain damage syndrome in the rat. II. Histopathological sequelae.

Nitecka L, Tremblay E, Charton G, Bouillot JP, Berger ML, Ben-Ari Y.
Neuroscience. 1984 Dec ; 13(4):1073-94.
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Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole : metabolic mapping using the deoxyglucose method withspecial reference to the pathology of epilepsy.

Ben-Ari Y, Tremblay E, Riche D, Ghilini G, Naquet R.
Neuroscience. 1981 ; 6(7):1361-91.
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A new model of focal status epilepticus: intra-amygdaloid application of kainic acid elicits repetitive secondarily generalized convulsive seizures.

Ben-Ari Y, Lagowska J, Tremblay E, Le Gal La Salle G.
Brain Res. 1979 Mar 9 ; 163(1):176-9.
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