Brain maturation

Commentary: GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo

Ben-Ari Y.
Commentary on the paper by K. Kirmse et al: GABA depolarizes immature neurons and inhibits network activity in the neonatal neocortex in vivo. Front. Cell. Neurosci, 2015 Dec 16; 10.3389
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The GABA excitatory/inhibitory developmental sequence: a personal journey.

Ben-Ari Y.
Neuroscience. 2014 Oct 24; 279:187-219
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Response to Comment on “Oxytocin-mediated GABA inhibition during delivery attenuates autism pathogenesis in rodent offspring”.

Eftekhari S, Shahrokhi A, Tsintsadze V, Nardou R, Brouchoud C, Conesa M, Burnashev N, Ferrari DC, Ben-Ari Y.
Science. 2014 Oct 10 ; 346 (6206): 176.
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Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring.

Tyzio R, Nardou R, Ferrari DC, Tsintsadze T, Shahrokhi A, Eftekhari S, Khalilov I, Tsintsadze V, Brouchoud C, Chazal G, Lemonnier E, Lozovaya N, Burnashev N, Ben-Ari Y.
Science. 2014 Feb 7 ; 343 (6171): 675-679.
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The developing cortex.

Ben-Ari Y.
Handb Clin Neurol. 2013;111:417-26.

Timing of developmental sequences in different brain structures: physiological and pathological implications.

Dehorter N, Vinay L, Hammond C, Ben-Ari Y.
Eur J Neurosci. 2012 Jun ; 35(12):1846-56.
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The GABA excitatory/inhibitory shift in brain maturation and neurological disorders.

Ben-Ari Y, Khalilov I, Kahle KT, Cherubini E.
Neuroscientist. 2012 Oct ; 18(5):467-86.
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Pioneer glutamatergic cells develop into a morphofunctionally distinct population in the juvenile CA3 hippocampus.

Marissal T, Bonifazi P, Picardo MA, Nardou R, Petit LF, Baude A, Fishell GJ, Ben-Ari Y, Cossart R.
Nat Commun. 2012 ; 3:1316.
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The immature brain needs GABA to be excited and hyper-excited.

Cherubini E, Ben-Ari Y.
J Physiol. 2011 May 15 ; 589(Pt 10):2655-6.
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Newborn Analgesia Mediated by Oxytocin during Delivery.

Mazzuca M, Minlebaev M, Shakirzyanova A, Tyzio R, Taccola G, Janackova S, Gataullina S, Ben-Ari Y, Giniatullin R, Khazipov R.
Front Cell Neurosci. 2011 Apr 12 ; 5:3.
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Depolarizing actions of GABA in immature neurons depend neither on ketone bodies nor on pyruvate.

Tyzio R, Allene C, Nardou R, Picardo MA, Yamamoto S, Sivakumaran S, Caiati MD, Rheims S, Minlebaev M, Milh M, Ferré P, Khazipov R, Romette JL, Lorquin J, Cossart R, Khalilov I, Nehlig A, Cherubini E, Ben-Ari Y.
J Neurosci. 2011 Jan 5 ; 31(1):34-45.
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Phenotypic checkpoints regulate neuronal development.

Ben-Ari Y, Spitzer NC.
Trends Neurosci. 2010 Nov ; 33(11):485-92.
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 A conserved switch in sensory processing prepares developing neocortex for vision.

Colonnese MT, Kaminska A, Minlebaev M, Milh M, Bloem B, Lescure S, Moriette G, Chiron C, Ben-Ari Y, Khazipov R.
Neuron. 2010 Aug 12 ; 67(3):480-98.
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GABAergic hub neurons orchestrate synchrony in developing hippocampal networks.

Bonifazi P, Goldin M, Picardo MA, Jorquera I, Cattani A, Bianconi G, Represa A, Ben-Ari Y, Cossart R.
Science. 2009 Dec 4 ; 326(5958):1419-24.
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NMDA receptors pattern early activity in the developing barrel cortex in vivo.

Minlebaev M, Ben-Ari Y, Khazipov R.
Cereb Cortex. 2009 Mar ; 19(3):688-96.
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Neuro-archaeology: pre-symptomatic architecture and signature of neurological disorders.

Ben-Ari Y.
Trends Neurosci. 2008 Dec ; 31(12):626-36.
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Sequential generation of two distinct synapse-driven network patterns in developing neocortex.

Allène C, Cattani A, Ackman JB, Bonifazi P, Aniksztejn L, Ben-Ari Y, Cossart R.
J Neurosci. 2008 Nov 26 ; 28(48):12851-63.
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GABA regulates stem cell proliferation before nervous system formation.

Wang DD, Kriegstein AR, Ben-Ari Y.
Epilepsy Curr. 2008 Sep-Oct ; 8(5):137-9.
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Excitatory GABA in rodent developing neocortex in vitro.

Rheims S, Minlebaev M, Ivanov A, Represa A, Khazipov R, Holmes GL, Ben-Ari Y, Zilberter Y.
J Neurophysiol. 2008 Aug ; 100(2):609-19.
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Effects of oxytocin on GABA signalling in the foetal brain during delivery.

Khazipov R, Tyzio R, Ben-Ari Y.
Prog Brain Res. 2008 ; 170:243-57.

GABA excites and sculpts immature neurons well before delivery: modulation by GABA of the development of ventricular progenitor cells.

Ben-Ari Y.
Epilepsy Curr. 2007 Nov-Dec ; 7(6):167-9.
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GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations.

Ben-Ari Y, Gaiarsa JL, Tyzio R, Khazipov R.
Physiol Rev. 2007 Oct ; 87(4):1215-84.
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Generation of slow network oscillations in the developing rat hippocampus after blockade of glutamate uptake.

Cattani AA, Bonfardin VD, Represa A, Ben-Ari Y, Aniksztejn L.
J Neurophysiol. 2007 Oct ; 98(4):2324-36.
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Rapid cortical oscillations and early motor activity in premature human neonate.

Milh M, Kaminska A, Huon C, Lapillonne A, Ben-Ari Y, Khazipov R
Cereb Cortex. 2007 Jul ; 17(7):1582-94.
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Inhibition of glutamate transporters results in a “suppression-burst” pattern and partial seizures in the newborn rat.

Milh M, Becq H, Villeneuve N, Ben-Ari Y, Aniksztejn L.
Epilepsia. 2007 Jan ; 48(1):169-74.
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Network mechanisms of spindle-burst oscillations in the neonatal rat barrel cortex in vivo.

Minlebaev M, Ben-Ari Y, Khazipov R.
J Neurophysiol. 2007 Jan ; 97(1):692-700.
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Paracrine intercellular communication by a Ca2+- and SNARE-independent release of GABA and glutamate prior to synapse formation.

Demarque M, Represa A, Becq H, Khalilov I, Ben-Ari Y, Aniksztejn L.
Neuron. 2002 Dec 19 ; 36(6):1051-61.
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Correlated bursts of activity in the neonatal hippocampus in vivo.

Leinekugel X, Khazipov R, Cannon R, Hirase H, Ben-Ari Y, Buzsáki G.
Science. 2002 Jun 14 ; 296(5575):2049-52.
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Early development of neuronal activity in the primate hippocampus in utero.

Khazipov R, Esclapez M, Caillard O, Bernard C, Khalilov I, Tyzio R, Hirsch J, Dzhala V, Berger B, Ben-Ari Y.
J Neurosci. 2001 Dec 15 ; 21(24):9770-81.
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Abnormal connections in the malformed cortex of rats with prenatal treatment with methylazoxymethanol may support hyperexcitability.

Chevassus-Au-Louis N, Jorquera I, Ben-Ari Y, Represa A.
Dev Neurosci. 1999 Nov ; 21(3-5):385-92.
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The establishment of GABAergic and glutamatergic synapses on CA1 pyramidal neurons is sequential and correlates with the development of the apical dendrite.

Tyzio R, Represa A, Jorquera I, Ben-Ari Y, Gozlan H, Aniksztejn L.
J Neurosci. 1999 Dec 1 ; 19(23):10372-82.
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Neuronal migration disorders: heterotopic neocortical neurons in CA1 provide a bridge between the hippocampus and the neocortex.

Chevassus-Au-Louis N, Congar P, Represa A, Ben-Ari Y, Gaïarsa JL.
Proc Natl Acad Sci USA. 1998 Aug 18 ; 95(17):10263-8.
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GABAA, NMDA and AMPA receptors: a developmentally regulated ‘ménage à trois’

Ben-Ari Y, Khazipov R, Leinekugel X, Caillard O, Gaiarsa JL.
Trends Neurosci. 1997 Nov ; 20(11):523-9.
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A novel in vitro preparation: the intact hippocampal formation.

Khalilov I, Esclapez M, Medina I, Aggoun D, Lamsa K, Leinekugel X, Khazipov R, Ben-Ari Y.
Neuron. 1997 Oct ; 19(4):743-9.
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Ca2+ oscillations mediated by the synergistic excitatory actions of GABA(A) and NMDA receptors in the neonatal hippocampus.

Leinekugel X, Medina I, Khalilov I, Ben-Ari Y, Khazipov R.
Neuron. 1997 Feb ; 18(2):243-55.
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Spontaneous release of GABA activates GABAB receptors and controls network activity in the neonatal rat hippocampus.

McLean HA, Caillard O, Khazipov R, Ben-Ari Y, Gaiarsa JL.
J Neurophysiol. 1996 Aug ; 76(2):1036-46.
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GABA: an excitatory transmitter in early postnatal life.

Cherubini E, Gaiarsa JL, Ben-Ari Y.
Trends Neurosci. 1991 Dec ; 14(12):515-9.
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Giant synaptic potentials in immature rat CA3 hippocampal neurones.

Ben-Ari Y, Cherubini E, Corradetti R, Gaiarsa JL.
J Physiol. 1989 Sep ; 416:303-25.
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